Author

Chiara Cassioli

University of SienaORCID 0000-0002-4853-2298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

Cosima T. BaldariiD· 3 shared Michael Loran DustiniD· 3 shared Bruce R. BlazariD· 2 shared Claire C. StatoniD· 2 shared Claudia SchirraiD· 2 shared Ewoud Bernardus CompeeriD· 2 shared Hsin‐Fang ChangiD· 2 shared Nagaja CapitaniiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Cosima T. BaldariORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles

Jemma H. Larson, Ewoud Bernardus Compeer, Phillip R. Dougherty, Kyle Smith, Michael C. Zaiken, Olga Margaritaki, Benn Kopp, Sujeong Jin, Maria Harkiolaki, Lina Chen, Salvatore Valvo, Claire C. Staton, Nagaja Capitani, Chiara Cassioli, Nathaniel C. Payne, , Bruce R. Blazar

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

bioRxiv · Jun 23, 2026 · PreprintImmunology

Interferon-γ promotes SMAP production by cytotoxic T lymphocytes in a thrombospondin 4 dependent manner

Omnia M. Khamis, Mohammad Shkeir, Claudia Schirra, Szu-Min Tu, Chiara Cassioli, Abed Alrahman Chouaib, Eve Lecomte, Lena Schoenecker, Michael Loran Dustin, Hsin‐Fang Chang, Cosima T. Baldari, Ute Becherer

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

bioRxiv · Jun 12, 2026 · PreprintImmunology

Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity

Chiara Cassioli, Nagaja Capitani, Claire C. Staton, Claudia Schirra, Francesca Finetti, Anna Onnis, Nadia Alawar, Szu-Min Tu, Ludovica Lopresti, Vanessa Tatangelo, Carmela Tangredi, Salvatore Valvo, Hsin‐Fang Chang, Annachiara Miccoli, Ewoud Bernardus Compeer, , Cosima T. Baldari

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

Proceedings of the National Academy of Sciences · Feb 4, 2025Peer-reviewedImmunology