A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease
Da Lin, Jeffrey Atkinson, Weidong Wu, Min Chen, Sohan Jayasekara, Benjamin M. Segal, Anjun Ma, Jie Gao
The paper shows that TREM2-dependent anabolic programs in microglia decline with advancing Alzheimer's disease, linking anabolic capacity to microglial resilience rather than activation state.
bioRxiv · Sep 20, 2026 · PreprintNeuroscience