Benjamin M. Segal

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

The paper shows that TREM2-dependent anabolic programs in microglia decline with advancing Alzheimer's disease, linking anabolic capacity to microglial resilience rather than activation state.

This study shows that aging of CNS-resident cells worsens EAE severity and reduces remission in mice, suggesting microglial activation and aging properties as therapeutic targets for progressive MS.

This study identifies efferocytosis as a key mechanism for nerve debridement following sciatic nerve injury through single-cell RNA-sequencing and genetic analysis.