Alpha-synuclein regulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-dependent manner
Elizabeth P. Rose, Valerie R. Osterberg, Jovin S. Banga, Vera A. Gorbunova, Vivek K. Unni
This study shows that alpha-synuclein regulates DNA double-strand break repair via DNA-PKcs in HAP1 cells and neurons, linking its dysfunction to genomic instability in neurodegenerative diseases.
Neurobiology of Disease · Sep 19, 2024Peer-reviewedNeuroscience