Vivek K. Unni

This study shows that the A53E mutation in alpha-synuclein reduces aggregation and phosphorylation in vivo, leading to delayed progression of Parkinson's disease.

This study investigates the protective effects of the APOE CC mutation against Aβ, tau, and α-synuclein pathologies in mouse models of neurodegenerative diseases.

This study shows alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma cells, affecting genomic stability and cancer progression.

This study shows that alpha-synuclein knockout in TG3 mice delays melanoma onset and slows tumor growth, with sex-dependent effects on DNA damage repair.

This study shows that alpha-synuclein regulates DNA double-strand break repair via DNA-PKcs in HAP1 cells and neurons, linking its dysfunction to genomic instability in neurodegenerative diseases.

This study shows that AQP4 mis-localization impairs glymphatic clearance of α-synuclein and promotes its aggregation and spread in neurodegenerative diseases.

This study shows that antisense oligonucleotides targeting alpha-synuclein reduce Lewy body pathology and improve cognitive and motor performance in a mouse model of synucleinopathy.