Pharmacology & ToxicologyEnvironmental Science & TechnologyPeer-reviewed
A Data-Driven Approach for the Development of a Time-informed Adverse Outcome Pathway-network for Cardiotoxicity of Environmental Chemicals
Alexandra Schaffert, Sivakumar Murugadoss, Tom Roos…·Martin Paparella
This paper develops a time-informed Adverse Outcome Pathway (AOP) network for environmental chemical-induced cardiotoxicity using data-driven methods and identifies key processes linking perturbations to cardiac injury.
DOI 10.1021/acs.est.6c00396