Contribution of systemic and somatic factors to clinical response and resistance in urothelial cancer: an exploratory multi-omic analysis
Alexandra Snyder, Tavi Nathanson, Samuel Aaron Funt, Arun Ahuja, Jacqueline L. Buros, Matthew David Hellmann, Eliza Chang, Bülent Arman Aksoy, Hikmat A Al‐Ahmadie, Erik C. Yusko, Marissa Vignali, Sharon Benzeno, Mariel Elena Boyd, Meredith Maisie Moran, Gopa Iyer, , Dean F. Bajorin
This study explores factors influencing response and resistance to atezolizumab in urothelial cancer using multi-omic data, finding associations between TCR clonality and clinical outcomes.
PLoS Medicine · May 26, 2017Peer-reviewedGenomics