Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood
Puneet Rawat, Melanie R. Shapiro, Leeana D. Peters, Michael Widrich, Koshlan Mayer-Blackwell, Keshav Motwani, Milena Pavlović, Ghadi al Hajj, Amanda L. Posgai, Chakravarthi Kanduri, Giulio Isacchini, Maria Chernigovskaya, Lonneke Scheffer, Kartik Motwani, Leandro Octavio Balzano-Nogueira, , Todd M. Brusko
The paper identifies TCR subsequence motifs associated with type 1 diabetes using deep learning and shows their enrichment in T1D individuals based on HLA risk alleles.
Science Advances · Feb 13, 2026Peer-reviewedGenetic & Genomic Medicine