The paper identifies rare protein-coding variants influencing plasma protein levels in 50,829 UK Biobank participants using exome-wide association studies.

bioRxiv · Oct 9, 2022 · PreprintGenomics

Cross-platform proteomics to advance genetic prioritisation strategies

Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Nicola D. Kerrison, Erin Oerton, Mine Koprulu, Jian’an Luan, Aroon Dinesh Hingorani, Steve A. Williams, Nicholas J. Wareham, Claudia Langenberg

The paper compares pQTLs across two proteomic platforms, finding shared and platform-specific pQTLs and identifying factors contributing to platform differences.

bioRxiv · Mar 18, 2021 · PreprintGenetics

Genetic architecture of host proteins interacting with SARS-CoV-2

Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Johannes Raffler, Nicola D. Kerrison, Erin Oerton, Victoria P.W. Auyeung, Jian’an Luan, Chris Finan, Juan Pablo Casas, Rachel M. Ostroff, Steve A. Williams, Gabi Kastenmüller, Markus Ralser, Eric R. Gamazon, , Claudia Langenberg

The paper integrates genomic and proteomic data to identify genetic variants influencing host proteins interacting with SARS-CoV-2, revealing potential drug targets and disease mechanisms.

bioRxiv · Jul 1, 2020 · PreprintGenomics