Author

Sebastian Wasilewski

AstraZeneca (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 4 Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 6 Assay:whole-genome sequencing· 4 Research Focus:gene regulatory network inference· 3 Research Focus:GWAS / association mapping· 3 Assay:whole-exome sequencing· 3 Research Focus:differential expression· 2 Approach:machine learning (classical)· 1

Frequent Co-Authors

Quanli WangiD· 7 shared Slavé PetrovskiiD· 7 shared Dimitrios VitsiosiD· 6 shared Ryan S. DhindsaiD· 6 shared Abhishek NagiD· 5 shared Sri V. V. DeeviiD· 5 shared Adam PlattiD· 4 shared Fengyuan HuiD· 4 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersGenetic & Genomic Medicine

Quanli WangORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease Susceptibility

Rahul Sharma, Fengyuan Hu, Xiaoyin Li, Rafael Campos, Kousik Kundu, Santosh S. Atanur, Marcin Karpiński, Sebastian Wasilewski, Stewart MacArthur, Dimitrios Vitsios, Ryan S. Dhindsa, Ilias Georgakopoulos‐Soares, Oliver S. Burren, Slavé Petrovski, Anthony M. Mustoe, , Xueqing Zoe Zou

The paper identifies non-coding G-quadruplex variants associated with plasma proteins and clinical traits, showing stronger signals when considering G4 stability impacts and integrating with protein-truncating variants.

medRxiv · Jun 1, 2026 · PreprintGenetic & Genomic Medicine

Clonal haematopoiesis without identified genetic drivers: insights from analyses of 407,512 individuals

Sean Wen, Rafael Campos, Marcin Karpiński, Rahul Sharma, Veselin Manojlović, Sri V. V. Deevi, Sean O’Dell, Xiaoyin Li, Fengyuan Hu, Jared O’Connell, Abhishek Nag, Karyn Mégy, Stewart MacArthur, Sebastian Wasilewski, Xueqing Zoe Zou, , Jonathan Mitchell

This study identifies 26,963 individuals with clonal haematopoiesis without known genetic drivers (CH-UD) and finds strong genetic and phenotypic links to other forms of clonal haematopoiesis, implicating TCL1A and epigenetic changes.

medRxiv · May 21, 2026 · PreprintGenetic & Genomic Medicine

Comparative analysis of 136,401 Admixed Americans and 419,228 Europeans reveals ancestry-specific genetic determinants of clonal haematopoiesis

Sean Wen, Pablo Antonio Kuri-Morales, Fengyuan Hu, Abhishek Nag, Ioanna Tachmazidou, Sri V. V. Deevi, Haeyam Taiy, Katherine R. Smith, Douglas P. Loesch, Oliver S. Burren, Ryan S. Dhindsa, Sebastian Wasilewski, Jesús Alegre-Díaz, Jaime Berumen-Campos, Jonathan Emberson, , Jonathan Mitchell

This study compares clonal haematopoiesis (CH) between admixed Americans and Europeans, finding ancestry-specific genetic factors and lower CH prevalence in admixed populations.

medRxiv · Feb 7, 2024 · PreprintGenetic & Genomic Medicine

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequences

Oliver S. Burren, Ryan S. Dhindsa, Sri V. V. Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Katherine R. Smith, Neetu Razdan, Henric Olsson, Adam Platt, Dimitrios Vitsios, Qiang Wu, AstraZeneca Genomics Initiative, Veryan Codd, , Slavé Petrovski

The paper identifies 53 rare variants and 22 genes associated with telomere length using UK Biobank whole-genome sequences, highlighting their role in clonal haematopoiesis and disease.

medRxiv · Sep 18, 2023 · PreprintGenetic & Genomic Medicine

Influences of rare protein-coding genetic variants on the human plasma proteome in 50,829 UK Biobank participants

Ryan S. Dhindsa, Oliver S. Burren, Benjamin B. Sun, Bram Peter Prins, Dorota Matelska, Eleanor Wheeler, Jonathan Mitchell, Erin Oerton, Ventzislava A. Hristova, Katherine R. Smith, Keren Carss, Sebastian Wasilewski, Andrew Robert Harper, Dirk S. Paul, Margarete A. Fabre, , Slavé Petrovski

The paper identifies rare protein-coding variants influencing plasma protein levels in 50,829 UK Biobank participants using exome-wide association studies.

bioRxiv · Oct 9, 2022 · PreprintGenomics

Surveying the contribution of rare variants to the genetic architecture of human disease through exome sequencing of 177,882 UK Biobank participants

Quanli Wang, Ryan S. Dhindsa, Keren Carss, Andrew Robert Harper, Abhishek Nag, Ioanna Tachmazidou, Dimitrios Vitsios, Sri V. V. Deevi, Alex Mackay, Daniel Muthas, Michael H. Hühn, Susan J. Monkley, Henric Olsson, Sebastian Wasilewski, Katherine R. Smith, , AstraZeneca Genomics Initiative

This study uses exome sequencing of 177,882 UK Biobank participants to assess the role of rare variants in 10,533 phenotypes, identifying 911 significant gene-phenotype relationships.

bioRxiv · Dec 13, 2020 · PreprintGenomics

Identification of a novel missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

Ryan S. Dhindsa, Johan Mattsson, Abhishek Nag, Quanli Wang, Louise V. Wain, Richard J. Allen, Eleanor M. Wigmore, Kristina Ibáñez, Dimitrios Vitsios, Sri V. V. Deevi, Sebastian Wasilewski, Maria Karlsson, Glenda Lassi, Henric Olsson, Daniel Muthas, , Slavé Petrovski

The paper identifies a novel missense variant in SPDL1 associated with idiopathic pulmonary fibrosis through genome-wide association analysis.

bioRxiv · Jun 29, 2020 · PreprintGenetics