Identification of Scaffold Specific Energy Transfer Networks in the Enthalpic Activation of Orotidine 5'-Monophosphate Decarboxylase
Pankaj Dubey, Anish Somani, Jessica Lin, Anthony T. Iavarone, Judith Pollock Klinman
This study identifies four thermally sensitive energy transfer networks in Mt-OMPDC that facilitate substrate activation by optimizing electrostatics and positioning of the reactive carboxylate.
bioRxiv · Jan 29, 2025 · PreprintBiochemistry