Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice
Supinder Kour Bali, Dawn Marie Bryce, Carina Prein, James Robert Woodgett, Frank Beier
This study shows that deleting both GSK3a and GSK3b in cartilage of juvenile mice causes premature growth plate remodeling, growth retardation, and early death, while articular cartilage is less affected.
Journal of Molecular Medicine · Feb 20, 2021Peer-reviewedDevelopmental Biology