2,2-Di-Fluoro-Derivatives of Fucose Can Inhibit Cell Surface Fucosylation Without Causing Slow Transfer to Acceptors
Yanyan Liu, Igor R. Sweet, Geert‐Jan Boons
This paper evaluates 2,2-di-fluoro-fucose derivatives as FUT inhibitors, finding they inhibit fucosylation without slow transfer to acceptors, and show feedback inhibition of GDP-Fuc biosynthesis.
JACS Au · Sep 23, 2024Peer-reviewedBiochemistry