Hoby P. Hetherington

Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio

This study shows that during adolescence, the prefrontal cortex's excitation/inhibition balance improves signal-to-noise ratio and working memory performance through changes in glutamate and GABA levels.

Aperiodic EEG and 7T MRSI evidence for maturation of E/I balance supporting the development of working memory through adolescence

The paper shows that changes in PFC aperiodic EEG activity and glutamate/GABA balance correlate with working memory development through adolescence.

Changes in prefrontal GABA and glutamate through adolescence supports excitation/inhibition balance

This study uses MRI to track changes in GABA and glutamate levels in the prefrontal cortex across adolescence, finding increased balance between these neurotransmitters.