Rare risk variants associate with epigenetic dysregulation in migraine
Tanya Ramdal Techlo, Mona Ameri Chalmer, Peter Loof Møller, Lisette J. A. Kogelman, Isa Amalie Olofsson, Karina Banasik, Mette Nyegaard, Jes Olesen, Thomas Folkmann Hansen
The paper identifies rare variants in the ASTN2 locus associated with migraine, independent of GWAS findings, and proposes a role for Polycomb Response Elements in migraine etiology.
medRxiv · Dec 20, 2021 · PreprintGenetic & Genomic Medicine