Jes Olesen

De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headaches

This study shows that levcromakalim-induced tactile hypersensitivity in mice involves eNOS and peroxynitrite, not classical NO-sGC-cGMP signaling, suggesting nitrosative stress as a therapeutic target for migraine.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

Rare risk variants associate with epigenetic dysregulation in migraine

The paper identifies rare variants in the ASTN2 locus associated with migraine, independent of GWAS findings, and proposes a role for Polycomb Response Elements in migraine etiology.

Changes in the gene expression profile during spontaneous migraine attacks

The paper investigates gene expression changes during spontaneous migraine attacks and identifies differentially expressed genes and pathways associated with migraine pathophysiology.