Author

Karl H. Obrietan

The Ohio State UniversityORCID 0000-0002-7525-7121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Kari R. HoytiD· 3 shared Nicklaus R. HalloyiD· 3 shared Megan FormanowicziD· 2 shared Joe William RamosiD· 1 shared Kelin L. WheatoniD· 1 shared Nguyen Nhi Lien Pham· 1 shared Tyler A Kyhl· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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3 shared papersNeuroscience

Kari R. HoytORCID

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Author profile →

3 papers

Recent·Most cited

Loss of PEA-15 Alters ERK/MAPK Signaling and Circadian Function in the Suprachiasmatic Nucleus

Kelin L. Wheaton, Nicklaus R. Halloy, Megan Formanowicz, Joe William Ramos, Kari R. Hoyt, Karl H. Obrietan

This study shows that loss of PEA-15 in mice affects circadian rhythms and ERK/MAPK signaling in the suprachiasmatic nucleus.

bioRxiv · Oct 27, 2026 · PreprintNeuroscience

Cellular- and systems-level profiling of amyloid-beta effects on circadian timing

Kari R. Hoyt, Tyler A Kyhl, Nicklaus R. Halloy, Karl H. Obrietan

This study examines how amyloid-beta affects circadian timing in the SCN and hippocampal neurons using 5xFAD mice and single-cell profiling, revealing differential sensitivity between central and peripheral clocks.

Neurobiology of Disease · Apr 12, 2026Peer-reviewedNeuroscience

Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of Tau pathology

Nicklaus R. Halloy, Megan Formanowicz, Nguyen Nhi Lien Pham, Kari R. Hoyt, Karl H. Obrietan

This study examines circadian timing and entrainment in the SCN of PS19 mice with tauopathy, finding no significant disruptions in core circadian mechanisms despite tau pathology.

Experimental Neurology · Sep 10, 2025Peer-reviewedNeuroscience