Explainable and Calibrated AI for Decoding Host-Adaptive Changes in Influenza A Virus
Huu-Tai Nguyen, Josip Rudar, Samira Mubareka, David Lapen, Yohannes Berhane, Carson Kai-Sang Leung, Oliver Lung
This paper introduces WaveSeekerNet, a calibrated AI model that predicts IAV host origin and identifies key adaptive mutations, revealing host-adaptive distance and the Mammalian Adaptation Zone.
bioRxiv · Jun 7, 2026 · PreprintGenomics