Cell BiologyEuropean Heart JournalPeer-reviewed
Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution
Lukas Zanders, Simone-Franziska Glaser, Mariano Ruz Jurado…·Stefanie Dimmeler
This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.