Author

Eike C. Nagel

Goethe University FrankfurtORCID 0000-0002-6044-950XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

David JohniD· 2 shared Mariano Ruz JuradoiD· 2 shared Stefanie DimmeleriD· 2 shared Tara Procida‐KowalskiiD· 2 shared Alisa Debes· 1 shared Andreas Michael ZeiheriD· 1 shared Anita TamiatoiD· 1 shared Ariane FischeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

David JohnORCID

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2 papers

Recent·Most cited

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution

Lukas Zanders, Simone-Franziska Glaser, Mariano Ruz Jurado, Moritz Brandt, David John, Luka Nicin, David Rodríguez Morales, Wesley Tyler Abplanalp, Tara Procida‐Kowalski, Franziska Ganß, Evelyn Ullrich, Alisa Debes, Penelope Pennoyer, Marek Bartkuhn, Reinhard B Dettmeyer, , Stefanie Dimmeler

This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.

European Heart Journal · Nov 1, 2025Peer-reviewedCell Biology

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina O. Püntmann, David John, Marcel H. Schulz, Eike C. Nagel, Stefanie Dimmeler, Guillermo Luxán

The paper identifies reduced STAT3 expression in cardiac pericytes in HFpEF and shows its loss leads to senescence and impaired adhesion.

FEBS Letters · May 1, 2025Peer-reviewedCell Biology