Andreas Michael Zeiher

The paper examines age-related clonal hematopoiesis and mosaic sex chromosome loss in UK Biobank participants, finding distinct proteomic programs and disease associations for each.

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

This study shows that loss of KDM6A in hematopoietic cells impairs cardiac recovery after heart failure by causing epigenetic changes in myeloid cells that increase inflammation and worsen cardiac outcomes.

This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.

This study identifies vascular niches as key hotspots for age-related inflammation and fibrosis in cardiac tissue using single-nucleus RNA sequencing and spatial transcriptomics.

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.

The paper introduces a cross-species integration pipeline for scRNA-seq data, validated on heart failure datasets from mice and humans, improving ortholog assignment and enabling pathway comparison.