Single-cell and spatial transcriptomic analyses of gene therapy-associatedretinal inflammation in non-human primates
Célia Sourd, Joel Quinn, Molly C. John, Cristina Martínez-Fernández de la Cámara, Lakshanie C. Wickramasinghe, Moustafa Attar, Hoda Shamsnajafabadi, Ahmed Salman, Sally A. Cowley, Calliope Athena Dendrou, Robert Edward MacLaren, Jasmina Cehajic‐Kapetanovic, Kanmin Xue
This study uses single-cell and spatial transcriptomics to analyze immune responses in non-human primates after retinal gene therapy, identifying persistent immune infiltration and cytokine-driven inflammation.
Molecular Therapy Advances · Mar 31, 2026Peer-reviewedImmunology