Author

Robert Edward MacLaren

John Radcliffe HospitalORCID 0000-0002-3096-4682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ahmed SalmaniD· 1 shared Alun R. BarnardiD· 1 shared Calliope Athena DendrouiD· 1 shared Célia SourdiD· 1 shared Cristina Martínez-Fernández de la CámaraiD· 1 shared Fiona Young· 1 shared Hoda ShamsnajafabadiiD· 1 shared Ian J. JacksoniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Ahmed SalmanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Single-cell and spatial transcriptomic analyses of gene therapy-associatedretinal inflammation in non-human primates

Célia Sourd, Joel Quinn, Molly C. John, Cristina Martínez-Fernández de la Cámara, Lakshanie C. Wickramasinghe, Moustafa Attar, Hoda Shamsnajafabadi, Ahmed Salman, Sally A. Cowley, Calliope Athena Dendrou, Robert Edward MacLaren, Jasmina Cehajic‐Kapetanovic, Kanmin Xue

This study uses single-cell and spatial transcriptomics to analyze immune responses in non-human primates after retinal gene therapy, identifying persistent immune infiltration and cytokine-driven inflammation.

Molecular Therapy Advances · Mar 31, 2026Peer-reviewedImmunology

The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification

Sally H. Cross, Lisa McKie, Toby W. Hurd, Sam Riley, Jimi C. Wills, Alun R. Barnard, Fiona Young, Robert Edward MacLaren, Ian J. Jackson

This paper identifies TMEM98 as a regulator of eye size by inhibiting MYRF self-cleavage, leading to abnormal nuclear localization and activation of MYRF in the absence of TMEM98.

PLoS Genetics · Apr 1, 2020Peer-reviewedGenetics