Gut bacteria degrade purines via the 2,8-dioxopurine pathway
Yuanyuan Liu, Zhiwei Zhou, John B. Jarman, Haoqing Chen, Michelle Miranda-Velez, Robert A. Terkeltaub, Dylan Dodd
The paper identifies a novel 2,8-dioxopurine pathway in gut bacteria that degrades purines, revealing a host-microbe symbiosis with therapeutic implications for hyperuricemia and gout.
Nature Microbiology · Aug 6, 2025Peer-reviewedMicrobiology