Systematic dissection of biases in whole-exome and whole-genome sequencing reveals major determinants of coding sequence coverage
Yury A. Barbitoff, Dmitrii E. Polev, Andrey Sergeyevich Glotov, Elena A. Serebryakova, Irina V. Shcherbakova, Artem M. Kiselev, Anna Aleksandrovna Kostareva, Oleg S. Glotov, Alexander V. Predeus
This study systematically evaluates coverage biases in whole-exome and whole-genome sequencing, finding that some WES platforms outperform others and that WES can match WGS in variant discovery.
Scientific Reports · Feb 6, 2020Peer-reviewedGenomics