This study identifies genetic correlations and pleiotropic loci between atopic dermatitis and five neuropsychiatric disorders, highlighting shared inflammatory pathways and potential drug targets.

Human Genomics · Jul 25, 2025Peer-reviewedGenetic & Genomic Medicine

Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis

Charalabos Antonatos, Ashley Budu‐Aggrey, Alexandros Pontikas, Adam Akritidis, Efstathia Pasmatzi, Aikaterini Tsiogka, Stamatios Gregoriou, Katerina Grafanaki, Lavinia Paternoster, Yiannis Vasilopoulos

The paper develops polygenic transcriptome risk scores (PTRSs) for atopic dermatitis using transcriptome-wide association studies and shows improved predictive accuracy when combined with traditional polygenic risk scores.

Journal of Translational Medicine · May 23, 2025Peer-reviewedGenetic & Genomic Medicine

Transcriptome-wide analyses delineate the genetic architecture of expression variation in atopic dermatitis

Charalabos Antonatos, Dimitra Mitsoudi, Alexandros Pontikas, Adam Akritidis, Panagiotis Xiropotamos, Georgios K. Georgakilas, Sophia Georgiou, Aikaterini Tsiogka, Stamatios Gregoriou, Katerina Grafanaki, Yiannis Vasilopoulos

This study identifies 176 gene-tissue associations in atopic dermatitis using transcriptome-wide association analysis, highlighting novel genes involved in allergic reactions, skin barrier integrity, and inflammation.

Human Genetics and Genomics Advances · Feb 26, 2025Peer-reviewedGenetic & Genomic Medicine