Molecular Basis of Histone H3 Reading and Writing by Legionella pneumophila SET Domain Lysine Methyltransferases
Stephen Gonzalez, Thomas Knight, Juan M. Nevarez, Alexandra H. Evans, Kayla M. Daniels, Emily L. Xu, Anup Vaidya, Jonathan M. Burg, Oluwatobi A. Adeleke, Shahrad Daraeikia, Saarang Gopinath, Michaela Yamine, Matthew Yacoub, Sojin An, Ethan Madison, , Raymond C. Trievel
This study investigates how Legionella pneumophila's SET domain enzymes methylate histone H3K14, revealing structural mechanisms for substrate specificity and nucleosome engagement.
bioRxiv · May 30, 2026 · PreprintBiochemistry