Johannes Hertel

Coupling of metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and resulting traits and diseases

The paper identifies gene-metabolite associations using exome sequencing and metabolomics, revealing graded effects of rare variants on traits and diseases.

Longitudinal flux balance analyses of a patient with Crohn's disease highlight microbiome metabolic alterations

This study uses longitudinal flux balance analysis of a Crohn's disease patient's microbiome to identify time-correlated metabolic alterations and their systemic effects.

Causal inference on microbiome-metabolome relations via in silico in vivo association pattern analyses

This paper develops a method to infer causal relationships between microbiome and metabolome in observational data using in silico in vivo association pattern analyses and validates it on a multi-omics dataset.

Integration of constraint-based modeling with fecal metabolomics reveals large deleterious effects of Fusobacteria species on community butyrate production

This study integrates constraint-based community modeling with fecal metabolomics to show Fusobacteria negatively impact butyrate production in gut microbiomes.

AGORA2: Large scale reconstruction of the microbiome highlights wide-spread drug-metabolising capacities.

AGORA2 reconstructs the human microbiome at scale, revealing individual-specific drug metabolism capabilities and correlations with clinical parameters.