The fungicide mancozeb induces astrocyte atrophy and disrupts Calcium signaling via inhibition of Orai1/STIM1-mediated SOCE
This study shows that mancozeb causes astrocyte atrophy and disrupts calcium signaling by inhibiting Orai1/STIM1-mediated SOCE, leading to altered neurotransmission and behavioral changes at concentrations below current safety limits.
bioRxiv · Jun 16, 2026 · PreprintPharmacology & Toxicology