Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in Mycobacterium tuberculosis Catalase-Peroxidase, KatG
Matthew W. Marney, Robert P. Metzger, David Hecht, Faramarz Valafar
This study analyzes 14 novel mutations in M. tuberculosis KatG using structural models to identify how they restrict access channels to the catalytic heme, potentially causing isoniazid resistance.
Tuberculosis · Nov 23, 2017Peer-reviewedGenomics