Author

David Hecht

San Diego State UniversityORCID 0000-0003-0949-2681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Faramarz ValafariD· 1 shared Matthew W. MarneyiD· 1 shared Robert P. MetzgeriD· 1 shared

Activity by Year

2017-2017 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperGenomics

Faramarz ValafarORCID

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1 paper

Recent·Most cited

GenomicsTuberculosisPeer-reviewedNov 23, 2017

Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in Mycobacterium tuberculosis Catalase-Peroxidase, KatG

Matthew W. Marney, Robert P. Metzger, David Hecht, Faramarz Valafar

This study analyzes 14 novel mutations in M. tuberculosis KatG using structural models to identify how they restrict access channels to the catalytic heme, potentially causing isoniazid resistance.

8 citations

humanprotein structure

𝕏 PostBluesky