Author

Steven G. Younkin

Mayo ClinicORCID 0000-0002-7818-3105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 3 Assay:whole-exome sequencing· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Joseph S. ReddyiD· 4 shared Minerva M. CarrasquilloiD· 4 shared Nilüfer Ertekin‐TaneriD· 4 shared Mariet AlleniD· 3 shared Todd Eliot GoldeiD· 3 shared Xue WangiD· 3 shared Yan W. AsmanniD· 3 shared Brandon J. CoombesiD· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Joseph S. ReddyORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJul 12, 2022

Polygenic risk score analysis identifies deleterious protein-coding variants in novel immune pathway genes ATP8B4, FCGR1A, and LILRB1 that associate with Alzheimer's disease.

Joseph S. Reddy, Xue Wang, Mariet Allen…·Steven G. Younkin

The paper identifies three novel immune pathway genes with deleterious variants associated with Alzheimer's disease using polygenic risk scores in whole exome sequence data.

2 citations

humanwhole-exome sequencing

GeneticsAlzheimer s & DementiaPeer-reviewedMay 18, 2021

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Vincent Damotte, Sven J. van der Lee, Vincent Antoine Chouraki…·Cornelia M. van Duijn

43 citations

humanGWAS summary statistics

NeurosciencebioRxivPreprintJan 18, 2021

Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

Xue Wang, Mariet Allen, Joseph S. Reddy…·Nilüfer Ertekin‐Taner

2 citations

humanbulk RNA-seq

GeneticsbioRxivPreprintNov 13, 2020

Identification of novel Alzheimer's disease genes co-expressed with TREM2

Joseph S. Reddy, Mariet Allen, Xue Wang…·Steven G. Younkin

The paper identifies four genes, including two novel ones, co-expressed with TREM2 in Alzheimer's disease using whole-exome data from ADSP.

1 citation

humanwhole-exome sequencing

GenomicsGenome biologyPeer-reviewedMay 19, 2019

Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight

Mark Ebbert, Tanner D. Jensen, Karen R. Jansen‐West…·John Denis Fryer

The paper identifies dark and camouflaged gene regions in the human genome, shows how long-read sequencing reduces their prevalence, and applies an algorithm to uncover disease-relevant variants in Alzheimer's Disease Sequencing Project data.

196 citationstop 1%

humanwhole-genome sequencing