Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID
Suman Shrestha, Matthew E. R. Maitland, Jing Li, Shili Duan, David Y. Nie, Jonathan R. St‐Germain, Michael Kanaris, Dalia Baršytė-Lovejoy, C.H. Arrowsmith, Brian Raught
This paper introduces ProtacID, a BioID-based method to identify PROTAC-proximal proteins, validates degradation targets, and identifies non-productive interactions in human cells.
Nature Communications · Aug 29, 2025Peer-reviewedMolecular Biology