Amy L Moore

A population-scale red blood cell proteome reveals genetically encoded aging clocks predictive of hemolysis and blood donor activity

This paper characterizes the RBC proteome across 13,091 donors, identifies genetic regulators of molecular aging, and shows that aging clocks predict hemolysis, transfusion outcomes, and donor activity.

Structural divergence of G6PD variants shapes red blood cell storage and transfusion performance

The paper investigates how G6PD variants affect red blood cell storage, transfusion performance, and recipient physiology using multiple datasets and experimental models.

Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus

This study investigates the genetic associations of early pregnancy C-reactive protein (CRP) levels with gestational diabetes mellitus (GDM) using maternal and offspring genome-wide association studies (GWAS).

Caffeine Impairs Red Blood Cell Storage Quality by Dual Inhibition of ADORA2b Signaling and G6PD Activity

Caffeine consumption and ADORA2b genetic variants impair RBC metabolism and transfusion outcomes through dual mechanisms, highlighting a modifiable interaction for precision transfusion strategies.

Evaluation of methods incorporating biological function and GWAS summary statistics to accelerate discovery

This study evaluates 18 functional weighting methods to enhance GWAS discovery, finding some methods can nominate high PPV variants for multiple traits without increasing sample size.

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.