Author

M.A. Christine Pratt

University of OttawaORCID 0000-0002-7894-5237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Aiman A. ZeiniD· 1 shared Tianqi JiangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperCancer Biology

Aiman A. ZeinORCID

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1 paper

Recent·Most cited

Cancer BiologyOncogenePeer-reviewedAug 11, 2026

The EGFR ligand amphiregulin regulates genomic integrity by facilitating heterochromatin formation in response to replication stress

Tianqi Jiang, Aiman A. Zein, M.A. Christine Pratt

This study shows that amphiregulin (AREG) in the nucleus helps maintain genomic stability by supporting heterochromatin formation during replication stress, especially in BRCA2 mutant cells.

DOI 10.1038/s41388-026-03940-4

humanproteomics