Author

Xinxiu Dong

Weifang University of Science and TechnologyORCID 0000-0002-7898-5327Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein sequence· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Approach:large language model· 1 Research Focus:protein design· 1 Research Focus:sequence-to-function modeling· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Jiawei LiiD· 1 shared Jiawei LiiD· 1 shared Jie LiuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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3 top collaborators · 1 mutual co-author link

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1 shared paperBioinformatics

Jiawei LiORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintNov 23, 2025

General-Purpose Large Language Models, such as DeepSeek V3.2, Have Evolved Protein Design Capabilities

Jiawei Li, Xinxiu Dong

This study shows that general-purpose LLMs like DeepSeek V3.2 can generate protein sequences with desired structures and improve solubility without biological training.

DOI 10.1101/2025.11.23.689994

protein sequencedeep learning

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMay 30, 2025

High-Codon: A Deep Learning-Based Codon Optimization Tool for Enhanced Heterologous Protein Expression in Escherichia coli

Jiawei Li, Xinxiu Dong, Jie Liu

High-Codon uses deep learning to optimize codons for improved protein expression in E. coli, outperforming traditional methods on 100 sequences from 34 species.

1 citation

E. coliprotein sequence

𝕏 PostBluesky