Dysfunctional vascular smooth muscle cells mediate early and late-stage neuroinflammation and Tau hyperphosphorylation
Jorge Alberto Aguilar-Pineda, Karin J. Vera-López, Pallavi Shrivastava, Rita Nieto-Montesinos, Miguel Á. Chávez‐Fumagalli, Gonzalo Dávila-Del-Carpio, Badhin Gómez Valdez, Clint L. Miller, Rajeev Kumar Malhotra, Mark Evan Lindsay, Christian Lacks Lino Cardenas
The paper shows that dysfunctional vascular smooth muscle cells contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer's disease through phenotypic transitions and loss of contractile markers.
bioRxiv · Apr 13, 2021 · PreprintNeuroscience