Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity
Rosanne C. van Deuren, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Marloes Steehouwer, Kajsa Sjöholm, Per-Arne Svensson, Marc Pieterse, Christian Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, Han G. Brunner, Mihai G. Netea, Markku Peltonen, Björn Carlsson, , Lena M.S. Carlsson
The paper shows that in individuals with obesity, mutation-driven haematopoietic clones grow faster with insulin resistance and low HDL-C, which are cardiovascular risk factors.
bioRxiv · May 12, 2021 · PreprintGenomics