Mihai Gheorghe Netea

The paper analyzes the gut microbiome and resistome in a Romanian cohort with high antibiotic use, identifying microbiome features, antimicrobial resistance patterns, and immune-related associations.

This study uses multi-omics clustering to identify three immunological endotypes in HIV patients, linking them to distinct HIV reservoir sizes and immune mechanisms.

The paper identifies uncharacterized genes differentially expressed in immune cells stimulated by pathogens and links them to rare immune disorders.

This study identifies genetic, intrinsic, and environmental factors influencing innate immune cytokine responses in four-year-old children, finding strong genetic and inflammatory biomarker associations.

The paper performs a federated cis-eQTL meta-analysis across single-cell datasets to identify cell-type-specific genetic effects and link them to disease mechanisms.

This study shows that HIV persistence accelerates immune aging in treated individuals, while certain antiretroviral drugs reduce it.

This study identifies phosphatidylserine as an anti-inflammatory biomarker and shows that HDL-associated PS reduces atherosclerosis through plaque stabilization and immune modulation in mice.

This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.

This study identifies a metabolic-epigenetic mechanism in oral epithelial cells that enhances protection against fungal infection through proline catabolism and mitochondrial function.

geneRNIB provides a benchmark for gene regulatory network inference, showing simpler models often outperform complex ones in perturbation-informed metrics.

This study examines how simulated Mars conditions affect immune responses to bacterial pathogens, finding altered cytokine secretion, ROS production, and phagocytic activity in human immune cells.

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

This study uses single-cell transcriptomics to identify immune responses and IL-1Ra-IL-1R evasion strategies in C. auris skin infection.

This study identifies early and delayed STAT1-dependent responses in splenic macrophages that drive trained immunity, enhancing protection against Salmonella Typhimurium infection.

This study shows BCG vaccination changes gene expression and chromatin accessibility in human bone marrow progenitor cells, linking these changes to innate immune responses.

This study reanalyzes exome sequencing data from 1,300 IEI patients, finding that systematic reanalysis increases the molecular diagnostic yield from 11.8% to 15.2%.

The paper compares the transcriptional responses of immune cells to three fungal pathogens in vitro, finding distinct expression patterns and a weaker response to cryptococcal stimuli.

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.

This study evaluates the diagnostic value of trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity, identifying DNVs in immune-related genes and providing functional evidence for FBXW11 mutations.

The paper integrates single-cell gene expression and circulatory protein data to identify genetic regulators of inflammation in response to Candida albicans.

This study identifies genetic variants influencing CCR5 expression on immune cells in HIV-positive and healthy individuals, showing cell-specific regulation and effects on inflammatory mediators.

This study explores the physiological significance of genetic variants associated with COVID-19 severity using clinical, immunological, and multi-omics data from large cohorts, identifying pathways for prevention and therapy.

This study examines how immune-related traits evolved in ancient and modern European populations, finding that the Neolithic transition influenced cytokine production and disease susceptibility.

This paper introduces Swarm Learning, a decentralized machine learning approach for disease classification using transcriptomic data, demonstrating its effectiveness in developing classifiers for COVID-19, tuberculosis, and leukemias while preserving privacy.

This study identifies associations between rare and common genetic variants in the IL-1 pathway and cytokine responses to various stimuli in healthy individuals.

The paper shows that in individuals with obesity, mutation-driven haematopoietic clones grow faster with insulin resistance and low HDL-C, which are cardiovascular risk factors.

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.

The paper analyzes genomic data from Mesolithic Scandinavians to show two colonization routes and genetic adaptations to high-latitude environments.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.