Thor Aspelund

This study examines the long-term temporal stability of 7,288 circulating proteins in older adults over five years, identifying factors like genetic effects and disease stage that influence stability.

This study identifies low-frequency genetic variants influencing serum protein levels, showing increased genetic signals and allelic heterogeneity in cis-regulation.

This study compares observational and Mendelian Randomization estimates of cardiometabolic proteomic signatures, finding that reverse causation predominantly shapes proteomic associations.

This study identifies a proteogenomic signature in blood associated with age-related macular degeneration, linking serum proteins to disease severity and progression.

This study identifies 4,113 genetic associations with serum proteins in 5,368 individuals, revealing shared loci between proteins and common diseases.

This study uses deep serum proteomics to identify 20 protein biomarkers for predicting type 2 diabetes and finds 48 proteins with causal roles in its development.

The paper identifies 2019 exome array variants affecting 2135 serum proteins and their association with hundreds of complex disease traits in the AGES Reykjavik cohort.

This study performs a large GWAS of Alzheimer's disease, identifies four new risk loci, and highlights pathways involving immunity, lipid metabolism, and APP/Aβ processing.