Joseph Loureiro

This study compares proteomic profiles of aqueous humor and plasma between glaucoma and non-glaucomatous patients, identifying differentially abundant proteins linked to vascular integrity, inflammation, and neurodegeneration.

This study examines the long-term temporal stability of 7,288 circulating proteins in older adults over five years, identifying factors like genetic effects and disease stage that influence stability.

This study identifies rapid remodeling of human subcutaneous white adipose tissue within one month after bariatric surgery using snRNA-seq, revealing changes in adipocyte populations and transcriptional dynamics.

This study identifies low-frequency genetic variants influencing serum protein levels, showing increased genetic signals and allelic heterogeneity in cis-regulation.

The paper identifies plasma proteins associated with diffusion tensor imaging biomarkers of white matter injury and suggests potential causal relationships using Mendelian randomization.

This study compares observational and Mendelian Randomization estimates of cardiometabolic proteomic signatures, finding that reverse causation predominantly shapes proteomic associations.

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

The paper evaluates the SomaScan proteome profiling platform using CCLE cancer cell lines, showing its ability to distinguish cell lines by proteome signatures and correlate with transcriptome data.

This study identifies a proteogenomic signature in blood associated with age-related macular degeneration, linking serum proteins to disease severity and progression.