Yuta Kochi

CATaN integrates TF-GRNs and transcriptomes to identify genetic risk components across complex diseases, finding 588 significant CC components enriched for SNP heritability.

The paper generates a comprehensive atlas of alternative splicing in human immune cells using long-read sequencing, identifies unannotated transcripts, and links isoforms to disease through quantitative trait loci and GWAS data.

The paper analyzes splicing QTLs focusing on coding sequences to identify disease-causal variants associated with GWAS traits through novel integration and selection approaches.

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

The paper uses empirical Bayes estimation of semi-parametric hierarchical mixture models to analyze GWAS summary statistics and characterize the polygenic architectures of schizophrenia and rheumatoid arthritis.