ATLAS: Population-Level Disease Locus Discovery via Differential Attention in Genomic Language Models
Yuqi Liu, Kaiwen Deng, Yuhua Ye, Zilin Wang, Jiajie Zhan, Shicheng Chen, Xinyue Hu, An Chang, Huijun Shen, Zhaorong Li, Shiping Liu, Xin Jin, Kui Chen, Xianzhi Qi, Xiangmin Xu, Haiqiang Zhang
Contrasting a pretrained genomic language model's attention between case and control haplotypes ranked HBB first on chromosome 11 and recovered more known β-thalassemia variants than GWAS, without per-variant tests.
ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD) · Aug 6, 2026Peer-reviewedGenetics✦ In-depth digest