Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathy
Laura R Mora, Mary Grace Bishop, Kayleigh Amber Rodriguez, Dakota M Redling, Renee Fox, Ashley M Ezeldin, Emma Zheng, Kimberly Stephens
In paclitaxel-treated mice, cold hypersensitivity outlasts mechanical hypersensitivity and coincides with reduced myelin gene expression, lower chromatin accessibility at Egr2/Yy1 motifs, and fragmented sciatic nerve myelin.
bioRxiv · Oct 7, 2026 · PreprintNeuroscience✦ In-depth digest