Ulrike Begley

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genes

The paper compares codon usage bias between oncogenes and tumor suppressor genes in humans and mice, finding distinct patterns in humans and less distinct in mice.

Genes and Pathways Comprising the Human and Mouse ORFeomes Display Distinct Codon Bias Signatures that Can Regulate Protein Levels

The paper analyzes codon bias in human and mouse ORFeomes to identify species-specific pathways regulated by translation, showing that extreme codon bias affects protein levels in transcription factors.