Mapping the Energy Landscape of PROTAC-Mediated Protein-protein Interactions
José A. Villegas, Tasneem M. Vaid, Michael E. Johnson, Terry W. Moore
The paper develops a method to restrict the search space for PROTAC-mediated protein-protein interactions using a cyclic coordinate descent algorithm, showing the global minimum corresponds to native-like conformations.
Computational and Structural Biotechnology Journal · Jan 1, 2023Peer-reviewedBioinformatics