Temporal Dynamics of High-Frequency Oscillations in Alzheimer's Disease: A Longitudinal Study in hAPP-J20 Mice
Keng‐Ying Liao, Xu Han, Wen‐Ying Chen, Wentai Liu, Yue Loong Hsin
This study identifies three stages of epileptogenic activity in hAPP-J20 mice, showing that neuronal hyperexcitability precedes amyloid plaque formation and suggests HFOs as potential biomarkers for early AD intervention.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience