Flux, toxicity and protein expression costs shape genetic interaction in a metabolic pathway
Harry E Kemble, Catherine Eisenhauer, Alejandro Couce, Audrey Chapron, Mélanie Magnan, Grégory Gautier, Hervé Le Nagard, Philippe Nghe, Olivier Tenaillon
The paper quantifies fitness interactions between expression variants of two metabolic genes across environments and shows these can be explained by a model incorporating catabolic flux, metabolite toxicity, and expression costs.
bioRxiv · Jul 27, 2018 · PreprintGenetics