Jennifer M. Colby

Dynamic Gating by the Phenylalanine Clamp Loop Controls Peptide Translocation Through the Anthrax Toxin Nanopore

This study investigates the role of the phenylalanine clamp loop in peptide translocation through the anthrax toxin nanopore using electrophysiology and mutant analysis, revealing its critical role in creating a hydrophobic trap.

Peptide hydrophobicity and aromaticity predict multi-state translocation kinetics via protective antigen nanopores

The paper uses single-molecule analysis to show how peptide hydrophobicity, aromaticity, and steric effects govern multi-state translocation through anthrax toxin PA nanopores.

Comparative study of nanopore phenylalanine clamp variants reveals unique peptide biosensing and classification properties

This study evaluates engineered nanopore variants for peptide biosensing and classification, finding that different variants excel in distinct tasks, suggesting the use of ensembles for improved performance.

High-performance machine learning for peptide classification from nanopore translocation events, leveraging event kinetics and duration filtering

This paper develops a machine learning framework for classifying peptides using nanopore translocation events, showing that engineered features and tree-based models achieve high accuracy.