Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficits
Jin Tao, Yang Yang, Yu Xing Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jin‐Tai Yu, Lan Ma, Feifei Wang
This study shows that NPTXs regulate engram network stability, and their downregulation in aging leads to memory deficits by causing hyperactivity in memory-related neuronal ensembles.
bioRxiv · May 19, 2025 · PreprintNeuroscience